High Performance Liquid Chromatography (HPLC)

Shimadzu LC-20AD Liquid Chromatograph

The system is equipped with two binary solvent pumps, a built-in degasser, a column oven, an autosampler, and is controlled by LabSolutions Workstation software. 

We also have a Pierce Reacti-Therm heating module for evaporating solvents as part of the sample preparation steps. 

Shimadzu LC-20AD Liquid Chromatograph

Methods Currently Available

Mycophenolic Acid & Mycophenolic Acid Glucuronide (MPA and MPAG)

Using a method modified from published literature, we are able to quantify mycophenolic acid and its glucuronide derivative from just 200 µL of plasma.  This is currently being used for a pharmacogenomics/pharmacokinetics research study for Dr. Laneshia Tague. 

Our analytical measuring range is

  • 0.06 – 50.0 mg/L (MPA)
  • 0.035 – 200.0 mg/L (MPAG)

Method Development

If you have a planned study with analytes that may be amenable to HPLC quantitation, please contact Dr. Jennifer Powers Carson (powers.jennifer.l@wustl.edu) to discuss feasibility and time frame of your study.

Cost will vary depending on how much method development is required and how many samples are anticipated.